Devastating Deliveries in anticlimatic

What are some lines from popular cinema that have flattened you, emotionally?

Some of mine, in no particular order or context:
(win one point for each movie recognized)

Thanks for always being there, Doc.

My friends, you bow to no one.

I like me. My wife likes me. My customers like me.

Look at him! That’s my brother goddamnit!

I’m the bad guy? I did everything they told me to do.